Clinical accuracy of the etiologic diagnosis in MCI

 
   Lead Investigator:    John Morris
   Institution      :    Washington University in St. Louis
   E-Mail           :    morrisj@abraxas.wustl.edu
   Proposal ID      :    300



   Proposal Description:
   Rather than a simple syndromic Uniform Data Set diagnosis of "mild cognitive impairment" (MCI), clinicians assigning a MCI diagnosis are required also to diagnose the probable cause of MCI.  This concept is embedded in recent diagnostic criteria for MCI developed by a Work Group from the National Institute on Aging and the Alzheimer Association, which no propose the term "MCI due to AD." However, how well clinicians can diagnose the underlying etiology of MCI remains to be evaluated.  Aim 1:  for any individual with a UDS diagnosis of MCI (all types) who came to autopsy, compare the clinical etiology of MCI with the neuropathological diagnosis  Aim 2:   for any individual with a CDR 0.5 and an etiological diagnosis of probable or possible AD, compare the clinical diagnosis with the neuropathological diagnosis  Aim 3:  compare the clinical diagnostic accuracy of the 3 groups (MCI, CDR 0.5/prob AD, CDR 0.5/poss AD)